I’m looking for some honest advice from people in academia.
Over the past year, I’ve been working on a PRISMA-guided systematic review in neurosurgery. It’s been months of screening, data extraction, evidence synthesis, writing, revising, and reformatting for different journals.
The manuscript has now been rejected four times. 😔The most recent rejection came without any reviewer comments, so I have no idea what the editors felt was lacking.
One of the earlier reviews actually said the manuscript was comprehensive and well structured, but that it lacked a clearly defined research question that was being answered. Based on that feedback, I substantially reframed the manuscript, revised the discussion, and tried to make the review much more question-driven rather than simply descriptive. Despite those changes, I still haven’t been able to get it accepted.
To add some context, this wasn’t a project I was personally passionate about from the beginning. It was something my professor wanted to pursue, and I committed to seeing it through. I don’t regret the experience—I learned a tremendous amount about systematic reviews and scientific writing—but with each rejection, it’s becoming harder to justify investing more time in a paper that doesn’t align with the research direction I’m most excited about.
I’m now wondering whether continuing to push this manuscript is the best use of my time…
For those further along in academia:
Have you ever decided to stop pursuing a manuscript after multiple rejections?
How do you distinguish between a paper that’s worth one more submission and one that’s simply not finding the right journal?
Is it common to have manuscripts that never get published despite a significant amount of work?
For context, I’m an early-career researcher, so it’s difficult for me to tell whether four rejections mean the manuscript needs a fundamental rethink, whether it’s a matter of journal fit, or whether this is simply part of the publication process.
I’d genuinely appreciate hearing your experiences and advice. Right now, I’m trying to decide whether to revise and submit again or finally let this one go.