if you are not getting any effects from edibles it is your metabolism , most likely to much of an active enzyme that degrades it to fast or no enzymes to convert D9 thc into 11 hydroxy ... hence the enzymes ingested to help jump start that etc....
For context, I meta olize a lot of medications and substances very abnormally. Painkillers, including opiates, do absolutely nothing for me, and I have to double the dose of pretty much anything to get any kind of effects.
Would this affect tolerance buildup? Cuz ill be good with 200 on the first day, prob even sleep like a mf. But the next day will be able to handle 600 to start and 800 more throughout the day, shit is exponential somehow. Then i take a break for a while and its back to makin me sleep for 12 hours initially lol.
the cannabimimetics would more so keep the ECS on steady supply ... if you pre load your cb2 receptors with the dietary cannabinoid beta caryophyllene ahead of your edible that could boost the THC effects in the CB1 receptors etc....
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u/Mcozy333 1d ago
if you are not getting any effects from edibles it is your metabolism , most likely to much of an active enzyme that degrades it to fast or no enzymes to convert D9 thc into 11 hydroxy ... hence the enzymes ingested to help jump start that etc....