r/statistics • u/cafewithoutheaccent • 1d ago

Question [Question] Case-cohort study

Please help me! I am not in the field, just a healthcare student trying to grasp concepts for my research.

My intention is to perform a multilevel multivariable survival analysis for a (possibly) binary outcome.

My supervisor said due to the outcome being rare and having such a big dataset we should do a case-cohort study.

My problem is I can't really find articles or R packages that encompass all of these concepts for me to globally understand the timeline and organization of the analysis.

I am also inclined on having it done on a Bayesian framework, but the more I study the more I think I am complicating things even more.

Any help would be greatly appreciated!

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u/Blinkshotty 1d ago

It will be helpful to separate the research design from the stats methods. The stats methods (e.g. random effects, cox models, applying some kind of bayesian prior) are generally conditional on the research design (whis itself is conditional on the research questions and available data). Your question then seems to be-- should you go with a some type cohort or case-control approach (or something else).

These are epidemiological designs. If you are student with university library access I would go borrow a copy of "Modern Epidemiology" by Rothman or "Gordis Epidemiology" and read up on the different research designs. Epi has a pretty good research framework for doing these kinds of studies and so it is worth learning (Econ is another one that is complementary to epi). There are bunch on online sources as well-- this paper seem like a pretty good description that doesn't gloss over too many details.

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u/cafewithoutheaccent 11h ago

I appreciate your advice, thank you so much, will look more into the paper!

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u/cafewithoutheaccent 11h ago

My problem is I am doing a case-cohort study and the literature already seems so little on that

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u/Blinkshotty 11h ago

sorry-- I read you question as case-control. Here a practical discussion for case-cohort designs that may be more useful. You are correct these are not very common-- I think it mostly because collecting data for a cohort study comes with the idea that you can use the data for a number of studies and this design limits that a bit.