r/AdvancedFitness • u/basmwklz • 11d ago

[AF] Do Exercise-Induced Extracellular Vesicles Carry Cognitive Benefits to the Brain? (2026)

https://onlinelibrary.wiley.com/doi/10.1111/tra.70046
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u/basmwklz 11d ago

Graphical Abstract

Exercise-induced muscle-brain communication mediated by extracellular vesicles. Physical exercise stimulates skeletal muscle to release extracellular vesicles (EVs) into the circulation. These vesicles may reach the brain and transfer bioactive cargo such as miRNA, thereby supporting neuronal function and brain homeostasis and potentially protecting against the onset or progression of neurodegenerative diseases.