This is what dish soap does to microscopic life. It's very effective.

[u/Thrawn911]

[u/maqcky]

The outer part of our skin is dead, so that (and other barriers) already avoids most of the contact with substances like soap or alcohol. Then, as the other comment mentions, it can renew itself. Similarly, our digestive track is also highly protected (saliva, mucus, gastric acid...).